Smg9 | SMG9 nonsense mediated mRNA decay factor

GeneMGI:1919247Synonyms: smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans), 1500002O20Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Nervous system Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal embryo size1 supporting datasetSmg9em1(IMPC)JheterozygoteE18.5N/A * 
abnormal behavior1 supporting datasetSmg9em1(IMPC)JheterozygoteEarly adult8.05x10-6 
decreased mean corpuscular hemoglobin concentration1 supporting datasetSmg9em1(IMPC)JheterozygoteEarly adult5.56x10-6 
preweaning lethality, complete penetrance1 supporting datasetSmg9em1(IMPC)JhomozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetSmg9em1(IMPC)JhomozygoteE18.5N/A * 
exencephaly1 supporting datasetSmg9em1(IMPC)JhomozygoteE18.5N/A * 
hyperactivity1 supporting datasetSmg9em1(IMPC)JheterozygoteEarly adult6.3x10-5 
preweaning lethality, complete penetrance1 supporting datasetSmg9tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
decreased thigmotaxis2 supporting datasetsSmg9em1(IMPC)JheterozygoteEarly adult8.03x10-6 
decreased circulating glucose level1 supporting datasetSmg9em1(IMPC)JheterozygoteEarly adult2.19x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Smg9em1(IMPC)JIndelmouse
Smg9tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Smg9tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Smg9tm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell

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