Tmco6 | transmembrane and coiled-coil domains 6

GeneMGI:1919233Synonyms: 2410015B03Rik

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Behavior/neurological Skeleton Mortality/aging

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

46Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	5 supporting datasets	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.01x10^-11
abnormal bone structure	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.34x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased startle reflex	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.57x10^-5
increased vertical activity	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.9x10^-6
decreased circulating calcium level	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.62x10^-9
increased total body fat amount	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.85x10^-5
decreased bone mineral content	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.49x10^-5
decreased locomotor activity	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.11x10^-5
decreased lean body mass	1 supporting dataset	Tmco6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.66x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmco6.

Associated images

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Histopathology

There is no histopathology data found for Tmco6.

IMPC related publications

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External links

No external links available for Tmco6.

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*Tmco6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Tmco6^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Tmco6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tmco6^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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