Fam53a | family with sequence similarity 53, member A

GeneMGI:1919225Synonyms: 5430419M09Rik, DNTNP, +1 more

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Nervous system Vision/eye Hematopoietic system Skeleton Cardiovascular system

10 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spine curvature	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.85x10^-5
enlarged thymus	2 supporting datasets	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	2 supporting datasets	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased prepulse inhibition	3 supporting datasets	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.21x10^-6
enlarged heart	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Fam53a^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.33x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fam53a.

Associated images

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Histopathology

There is no histopathology data found for Fam53a.

IMPC related publications

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External links

No external links available for Fam53a.

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*Fam53a^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Fam53a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Fam53a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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