Slc25a18 | solute carrier family 25 (mitochondrial carrier), member 18

GeneMGI:1919053Synonyms: 1500015I14Rik

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Nervous system Behavior/neurological Skeleton

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:

Life Stage:



increased bone mineral content	1 supporting dataset	Slc25a18^em1(IMPC)Mbp	homozygote	Early adult	6.53x10^-5
absent seminal vesicle	1 supporting dataset	Slc25a18^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Slc25a18^{tm1b(KOMP)Wtsi}	homozygote	Late adult	9.01x10^-5
decreased locomotor activity	1 supporting dataset	Slc25a18^em1(IMPC)Mbp	homozygote	Early adult	7.36x10^-11
increased circulating alanine transaminase level	1 supporting dataset	Slc25a18^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.53x10^-10
decreased anxiety-related response	1 supporting dataset	Slc25a18^em1(IMPC)Mbp	homozygote	Early adult	2.3x10^-12
abnormal behavior	1 supporting dataset	Slc25a18^em1(IMPC)Mbp	homozygote	Early adult	3.6x10^-12
enlarged epididymis	1 supporting dataset	Slc25a18^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
impaired cued conditioning behavior	1 supporting dataset	Slc25a18^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.99x10^-5
abnormal brain morphology	1 supporting dataset	Slc25a18^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc25a18.

Associated images

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Histopathology

There is no histopathology data found for Slc25a18.

IMPC related publications

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External links

No external links available for Slc25a18.

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*Slc25a18^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Slc25a18^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Slc25a18^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Slc25a18^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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