Vwa8 | von Willebrand factor A domain containing 8

GeneMGI:1919008Synonyms: 4932416F07Rik, 1300010F03Rik

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Cardiovascular system

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating potassium level	1 supporting dataset	Vwa8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.14x10^-7
abnormal vitreous body morphology	1 supporting dataset	Vwa8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.29x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Vwa8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.44x10^-5
abnormal retina morphology	1 supporting dataset	Vwa8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.17x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Vwa8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.87x10^-6
increased fasting circulating glucose level	1 supporting dataset	Vwa8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.03x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vwa8.

Associated images

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Histopathology

There is no histopathology data found for Vwa8.

IMPC related publications

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External links

No external links available for Vwa8.

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*Vwa8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Vwa8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Vwa8^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Vwa8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Vwa8^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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