Tmprss6 | transmembrane serine protease 6

GeneMGI:1919003Synonyms: 1300008A22Rik, matriptase-2

Physiological systems

15 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

4 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/ hair morphology	3 supporting datasets	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.96x10^-8
increased Ly6C-positive mature NK cell number	1 supporting dataset	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.61x10^-6
abnormal coat/hair pigmentation	6 supporting datasets	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.66x10^-9
decreased prepulse inhibition	8 supporting datasets	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.04x10^-9
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.72x10^-6
increased heart weight	1 supporting dataset	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.95x10^-5
increased circulating calcium level	1 supporting dataset	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.82x10^-6
short tibia	2 supporting datasets	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.11x10^-37
decreased NK cell number	1 supporting dataset	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.24x10^-6
decreased locomotor activity	4 supporting datasets	Tmprss6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.15x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmprss6.

Associated images

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Histopathology

There is no histopathology data found for Tmprss6.

IMPC related publications

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External links

No external links available for Tmprss6.

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*Tmprss6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tmprss6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tmprss6^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tmprss6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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