Pnpt1 | polyribonucleotide nucleotidyltransferase 1

GeneMGI:1918951Synonyms: PNPase, polynucleotide phosphorylase, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

6Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased mean corpuscular volume	1 supporting dataset	Pnpt1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.06x10^-11
decreased circulating HDL cholesterol level	1 supporting dataset	Pnpt1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.72x10^-5
abnormal gait	1 supporting dataset	Pnpt1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	6.53x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Pnpt1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Pnpt1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	5.14x10^-7
abnormal rib morphology	1 supporting dataset	Pnpt1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pnpt1.

Associated images

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Histopathology

There is no histopathology data found for Pnpt1.

IMPC related publications

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External links

No external links available for Pnpt1.

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*Pnpt1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pnpt1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Pnpt1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pnpt1^{tm301213(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Pnpt1^{tm37613(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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