Wdr27 | WD repeat domain 27

GeneMGI:1918932Synonyms: 0610012K18Rik

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	2 supporting datasets	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating iron level	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.96x10^-6
decreased circulating cholesterol level	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.32x10^-5
increased red blood cell distribution width	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.26x10^-5
thick ventricular wall	2 supporting datasets	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.69x10^-7
enlarged spleen	2 supporting datasets	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.85x10^-5
increased cardiac output	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.46x10^-5
abnormal retina morphology	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.07x10^-7
increased heart rate	1 supporting dataset	Wdr27^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.67x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wdr27.

Associated images

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Histopathology

There is no histopathology data found for Wdr27.

IMPC related publications

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External links

No external links available for Wdr27.

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*Wdr27^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Wdr27^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Wdr27^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Wdr27^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Wdr27^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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