Ints10 | integrator complex subunit 10

GeneMGI:1918135Synonyms: 4921521J11Rik

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal heart morphology	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal embryo turning	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal chorioallantoic fusion	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
decreased circulating creatinine level	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.79x10^-5
abnormal embryo size	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.64x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Ints10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ints10.

Associated images

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Histopathology

There is no histopathology data found for Ints10.

IMPC related publications

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External links

No external links available for Ints10.

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*Ints10^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ints10^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ints10^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ints10^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ints10^{tm3a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ints10^{tm42337(L1L2_Pgk_PM)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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