Hars2 | histidyl-tRNA synthetase 2

GeneMGI:1918041Synonyms: 4631412B19Rik, HO3, +2 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Hearing/vestibular/ear Behavior/neurological Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased grip strength	2 supporting datasets	Hars2^em1(IMPC)J	heterozygote	Early adult	2.02x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Hars2^em1(IMPC)J	homozygote	E9.5	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Hars2^em1(IMPC)J	heterozygote	Early adult	1.25x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Hars2^em1(IMPC)J	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hars2.

Associated images

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Histopathology

There is no histopathology data found for Hars2.

IMPC related publications

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External links

No external links available for Hars2.

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*Hars2^em1(IMPC)J*	Exon Deletion	‌	mouse
*Hars2^{tm79396(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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