Dusp16 | dual specificity phosphatase 16

GeneMGI:1917936Synonyms: MKP7, MKP-7, +2 more

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Nervous system Hematopoietic system Skeleton Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	7.15x10^-5
enlarged lymph nodes	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased heart weight	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	6.8x10^-5
enlarged spleen	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased erythrocyte cell number	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	2.81x10^-9
abnormal bone structure	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	2.51x10^-6
decreased hemoglobin content	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	4.45x10^-5
decreased prepulse inhibition	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	6.05x10^-6
abnormal uterus morphology	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Dusp16^em1(IMPC)Tcp	homozygote	Early adult	2.33x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dusp16.

Associated images

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Histopathology

There is no histopathology data found for Dusp16.

IMPC related publications

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External links

No external links available for Dusp16.

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*Dusp16^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Dusp16^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dusp16^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Dusp16^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Dusp16^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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