Arhgap17 | Rho GTPase activating protein 17

GeneMGI:1917747Synonyms: Rich1, WBP15, +3 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Skeleton

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased transitional stage T1 B cell number	2 supporting datasets	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.2x10^-6
decreased bone mineral content	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.51x10^-5
decreased circulating fructosamine level	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.74x10^-7
decreased B-1a cell number	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating glucose level	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.13x10^-5
decreased mature B cell number	2 supporting datasets	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.92x10^-5
decreased follicular B cell number	1 supporting dataset	Arhgap17^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgap17.

Associated images

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Histopathology

There is no histopathology data found for Arhgap17.

IMPC related publications

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External links

No external links available for Arhgap17.

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*Arhgap17^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Arhgap17^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Arhgap17^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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