Dop1b | DOP1 leucine zipper like protein B

GeneMGI:1917278Synonyms: Dopey2, 2610510B01Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating free fatty acids level	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.81x10^-6
increased leukocyte cell number	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.68x10^-5
increased blood urea nitrogen level	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.65x10^-5
increased lean body mass	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.96x10^-5
abnormal coat appearance	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.54x10^-5
increased grip strength	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.75x10^-5
increased bone mineral density	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.65x10^-7
increased bone mineral content	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.58x10^-6
decreased circulating glycerol level	1 supporting dataset	Dop1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.3x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dop1b.

Associated images

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Histopathology

There is no histopathology data found for Dop1b.

IMPC related publications

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External links

No external links available for Dop1b.

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*Dop1b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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