Fbxo7 | F-box protein 7

GeneMGI:1917004Synonyms: 2410015K21Rik, A230052G17Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Hematopoietic system

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased red blood cell distribution width	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.74x10^-40
decreased circulating iron level	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.35x10^-13
decreased erythrocyte cell number	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.69x10^-20
decreased hemoglobin content	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.23x10^-14
thrombocytosis	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.8x10^-12
decreased hematocrit	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.01x10^-16
decreased circulating fructosamine level	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.07x10^-8
increased circulating bilirubin level	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.26x10^-10
increased circulating sodium level	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.52x10^-5
male infertility	1 supporting dataset	Fbxo7^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxo7.

Associated images

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Histopathology

There is no histopathology data found for Fbxo7.

IMPC related publications

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External links

No external links available for Fbxo7.

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*Fbxo7^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Fbxo7^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Fbxo7^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbxo7^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Fbxo7^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Fbxo7^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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