Ttl | tubulin tyrosine ligase

GeneMGI:1916987Synonyms: 2410003M22Rik, 2700049H19Rik

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Ttl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Ttl^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.37x10^-12
edema	1 supporting dataset	Ttl^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ttl.

Associated images

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Histopathology

There is no histopathology data found for Ttl.

IMPC related publications

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External links

No external links available for Ttl.

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*Ttl^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ttl^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ttl^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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