Card11 | caspase recruitment domain family, member 11

GeneMGI:1916978Synonyms: 2410011D02Rik, 0610008L17Rik, +2 more

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small testis	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased effector memory T-helper cell number	2 supporting datasets	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.24x10^-17
small spleen	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.49x10^-8
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.96x10^-39
increased CD8-positive, naive alpha-beta T cell number	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.5x10^-14
increased leukocyte cell number	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.17x10^-9
enlarged thymus	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased T cell number	1 supporting dataset	Card11^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.28x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Card11.

Associated images

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Histopathology

There is no histopathology data found for Card11.

IMPC related publications

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External links

No external links available for Card11.

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*Card11^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Card11^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Card11^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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