Rpain | RPA interacting protein

GeneMGI:1916973Synonyms: 2400006N03Rik

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Hearing/vestibular/ear Vision/eye Behavior/neurological Cardiovascular system Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

embryonic lethality prior to organogenesis1 supporting datasetRpainem1(IMPC)JhomozygoteE9.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetRpainem1(IMPC)JhomozygoteEarly adultN/A * 
decreased grip strength1 supporting datasetRpainem1(IMPC)JheterozygoteEarly adult4.07x10-5 
abnormal auditory brainstem response1 supporting datasetRpainem1(IMPC)JheterozygoteEarly adult4.22x10-5 
abnormal retina blood vessel morphology1 supporting datasetRpainem1(IMPC)JheterozygoteEarly adult3.89x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rpainem1(IMPC)JExon Deletionmouse
Rpaintm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Rpaintm33815(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Rpaintm3a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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