Arap1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

GeneMGI:1916960Synonyms: Centd2, 2410002L19Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	1 supporting dataset	Arap1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.85x10^-11
decreased mean corpuscular hemoglobin	1 supporting dataset	Arap1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.01x10^-6
decreased pulmonary ventilation	1 supporting dataset	Arap1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.34x10^-6
decreased pulmonary respiratory rate	1 supporting dataset	Arap1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.26x10^-5
abnormal vocalization	1 supporting dataset	Arap1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.55x10^-5
short tibia	1 supporting dataset	Arap1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.94x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arap1.

Associated images

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Histopathology

There is no histopathology data found for Arap1.

IMPC related publications

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External links

No external links available for Arap1.

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*Arap1^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Arap1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Arap1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Arap1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Arap1^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Arap1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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