Arhgef12 | Rho guanine nucleotide exchange factor 12

GeneMGI:1916882Synonyms: LARG, 2310014B11Rik

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Embryo Growth/size/body region Nervous system Behavior/neurological Cardiovascular system Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic growth retardation	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
increased prepulse inhibition	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.84x10^-7
embryonic growth retardation	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
enlarged heart	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal heart shape	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
decreased locomotor activity	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.08x10^-5
abnormal heart morphology	1 supporting dataset	Arhgef12^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef12.

Associated images

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Histopathology

There is no histopathology data found for Arhgef12.

IMPC related publications

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External links

No external links available for Arhgef12.

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*Arhgef12^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Arhgef12^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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