Plekhm2 | pleckstrin homology domain containing, family M (with RUN domain) member 2

GeneMGI:1916832Synonyms: 2310034J19Rik

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased hemoglobin content	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.21x10^-5
decreased hematocrit	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.32x10^-5
increased leukocyte cell number	2 supporting datasets	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.05x10^-7
decreased mean corpuscular volume	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.71x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.39x10^-6
decreased body weight	2 supporting datasets	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.23x10^-6
decreased circulating fructosamine level	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.14x10^-8
increased lean body mass	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.18x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.67x10^-5
decreased erythrocyte cell number	1 supporting dataset	Plekhm2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.56x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plekhm2.

Associated images

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Histopathology

There is no histopathology data found for Plekhm2.

IMPC related publications

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External links

No external links available for Plekhm2.

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*Plekhm2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Plekhm2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Plekhm2^{tm44411(L1L2_gt1_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Plekhm2^{tm44411(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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