Vkorc1l1 | vitamin K epoxide reductase complex, subunit 1-like 1

GeneMGI:1916818Synonyms: 2310024K08Rik

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating cholesterol level1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult3.94x10-5 
hyperactivity8 supporting datasetsVkorc1l1em1(IMPC)JhomozygoteEarly adult5.35x10-17 
decreased circulating serum albumin level1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult3.59x10-5 
decreased circulating total protein level1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult4.9x10-5 
decreased leukocyte cell number1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult9.11x10-7 
decreased circulating calcium level1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult9.24x10-7 
increased fasting circulating glucose level1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult3.41x10-42 
increased mean corpuscular hemoglobin1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult1.78x10-17 
increased lean body mass1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult8.97x10-5 
decreased bone mineral content1 supporting datasetVkorc1l1em1(IMPC)JhomozygoteEarly adult9.95x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Vkorc1l1em1(IMPC)JExon Deletionmouse
Vkorc1l1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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