Klhdc2 | kelch domain containing 2

GeneMGI:1916804Synonyms: HCLP-1, D12Ertd522e, +1 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Craniofacial

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased neutrophil cell number	2 supporting datasets	Klhdc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.38x10^-20
abnormal skin morphology	1 supporting dataset	Klhdc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal head morphology	1 supporting dataset	Klhdc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.29x10^-5
cornea opacity	1 supporting dataset	Klhdc2^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	5.9x10^-5
increased circulating creatinine level	1 supporting dataset	Klhdc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.25x10^-11
tremors	1 supporting dataset	Klhdc2^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.66x10^-5
decreased locomotor activity	1 supporting dataset	Klhdc2^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	6.78x10^-6
abnormal snout morphology	1 supporting dataset	Klhdc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.84x10^-5
decreased lymphocyte cell number	1 supporting dataset	Klhdc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.24x10^-16
preweaning lethality, complete penetrance	1 supporting dataset	Klhdc2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Klhdc2.

Associated images

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Histopathology

There is no histopathology data found for Klhdc2.

IMPC related publications

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External links

No external links available for Klhdc2.

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*Klhdc2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Klhdc2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Klhdc2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Klhdc2^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Klhdc2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Klhdc2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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