Klk10 | kallikrein related-peptidase 10

GeneMGI:1916790Synonyms: NES1, PRSSL1, +1 more

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Hematopoietic system Cardiovascular system

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged thymus	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal sinus arrhythmia	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.79x10^-11
decreased hematocrit	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.28x10^-5
decreased hemoglobin content	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.57x10^-5
abnormal thymus morphology	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased effector memory CD8-positive, alpha-beta T cell number	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.3x10^-20
cardiovascular system phenotype	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.08x10^-6
increased effector memory T-helper cell number	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.6x10^-5
decreased CD8-positive, naive alpha-beta T cell number	1 supporting dataset	Klk10^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.14x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Klk10.

Associated images

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Histopathology

There is no histopathology data found for Klk10.

IMPC related publications

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External links

No external links available for Klk10.

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*Klk10^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Klk10^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Klk10^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Klk10^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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