Isca1 | iron-sulfur cluster assembly 1
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Behavior/neurological Mortality/aging
18 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| decreased exploration in new environment | 2 supporting datasets | Isca1tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.83x10-6 | ||
| decreased vertical activity | 1 supporting dataset | Isca1tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.25x10-5 | ||
| decreased locomotor activity | 2 supporting datasets | Isca1tm1b(KOMP)Wtsi | heterozygote | Early adult | 7.4x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Isca1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Isca1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Isca1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
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External links
No external links available for Isca1.
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| Isca1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Isca1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |