Wdr53 | WD repeat domain 53

GeneMGI:1916230Synonyms: 1500002B03Rik

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating total protein level1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult1.37x10-5 
increased circulating HDL cholesterol level1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult3.79x10-5 
decreased circulating glucose level1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult1.59x10-9 
increased hematocrit1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult6.78x10-6 
increased circulating bilirubin level1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult4.47x10-5 
increased erythrocyte cell number1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult1.46x10-8 
increased circulating cholesterol level1 supporting datasetWdr53em1(IMPC)JhomozygoteEarly adult2.77x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Wdr53em1(IMPC)JIntra-exon deletionmouse
Wdr53tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Wdr53tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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