Chmp2b | charged multivesicular body protein 2B

GeneMGI:1916192Synonyms: 1190006E07Rik, chromatin modifying protein 2B

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging Renal/urinary system

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



no spontaneous movement	2 supporting datasets	Chmp2b^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
abnormal spleen morphology	2 supporting datasets	Chmp2b^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
no spontaneous movement	2 supporting datasets	Chmp2b^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
abnormal kidney morphology	1 supporting dataset	Chmp2b^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged spleen	2 supporting datasets	Chmp2b^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
prolonged RR interval	1 supporting dataset	Chmp2b^em1(IMPC)Mbp	heterozygote	Early adult	9.35x10^-6
decreased heart rate	1 supporting dataset	Chmp2b^em1(IMPC)Mbp	heterozygote	Early adult	5.08x10^-5
hydrometra	1 supporting dataset	Chmp2b^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Chmp2b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Chmp2b^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chmp2b.

Associated images

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Histopathology

There is no histopathology data found for Chmp2b.

IMPC related publications

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External links

No external links available for Chmp2b.

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*Chmp2b^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Chmp2b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Chmp2b^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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