Ppil1 | peptidylprolyl isomerase (cyclophilin)-like 1

GeneMGI:1916066Synonyms: 1110060O10Rik, Cypl1

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	7.49x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Ppil1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	2.94x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Ppil1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
increased circulating creatinine level	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	1.34x10^-6
microphthalmia	1 supporting dataset	Ppil1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppil1.

Associated images

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Histopathology

There is no histopathology data found for Ppil1.

IMPC related publications

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External links

No external links available for Ppil1.

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*Ppil1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ppil1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ppil1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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