Elovl5 | ELOVL fatty acid elongase 5

GeneMGI:1916051Synonyms: 1110059L23Rik, ELOVL family member 5, elongation of long chain fatty acids (yeast)

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased red blood cell distribution width	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	3.63x10^-6
increased fasting circulating glucose level	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	9.13x10^-6
decreased locomotor activity	3 supporting datasets	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	2.59x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	7.24x10^-8
cataract	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	2.73x10^-6
abnormal lens morphology	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	1.92x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	7.34x10^-7
improved glucose tolerance	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	8.78x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	1.23x10^-8
decreased lean body mass	2 supporting datasets	Elovl5^em1(IMPC)Tcp	homozygote	Early adult	1.24x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Elovl5.

Associated images

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Histopathology

There is no histopathology data found for Elovl5.

IMPC related publications

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External links

No external links available for Elovl5.

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*Elovl5^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Elovl5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Elovl5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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