Rab3gap2 | RAB3 GTPase activating protein subunit 2

GeneMGI:1916043Synonyms: 1110059F07Rik

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Craniofacial

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

5Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased heart rate	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.45x10^-5
narrow eye opening	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.57x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.04x10^-6
decreased hematocrit	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.07x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.08x10^-5
increased circulating bilirubin level	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.43x10^-6
hyperactivity	6 supporting datasets	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.64x10^-6
prolonged RR interval	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.36x10^-5
thrombocytopenia	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.6x10^-5
cataract	1 supporting dataset	Rab3gap2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.39x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rab3gap2.

Associated images

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Histopathology

There is no histopathology data found for Rab3gap2.

IMPC related publications

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External links

No external links available for Rab3gap2.

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*Rab3gap2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rab3gap2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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