Rabl2 | RAB, member RAS oncogene family-like 2

GeneMGI:1915958Synonyms: Rabl2a, 1110031N17Rik

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral content	2 supporting datasets	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.03x10^-9
decreased lean body mass	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	2.22x10^-9
abnormal digit morphology	4 supporting datasets	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	2.34x10^-19
eye hemorrhage	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	3.4x10^-8
abnormal nail morphology	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	2.34x10^-19
abnormal testis morphology	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.4x10^-7
abnormal autopod morphology	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	2.34x10^-19
impaired glucose tolerance	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.37x10^-7
decreased bone mineral density	1 supporting dataset	Rabl2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	2.41x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rabl2.

Associated images

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Histopathology

There is no histopathology data found for Rabl2.

IMPC related publications

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External links

No external links available for Rabl2.

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*Rabl2^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Rabl2^{tm1.1(KOMP)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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