Klk5 | kallikrein related-peptidase 5

GeneMGI:1915918Synonyms: 1110030O19Rik

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

36Embryo tissues

Phenotypes

Phy. System:



abnormal vitreous body morphology	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.27x10^-7
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	6.72x10^-9
abnormal retina blood vessel morphology	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	3.61x10^-5
abnormal auditory brainstem response	3 supporting datasets	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.32x10^-8
increased red blood cell distribution width	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.39x10^-7
long tibia	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.57x10^-11
decreased total retina thickness	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	4.29x10^-6
abnormal retina morphology	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.9x10^-12
decreased locomotor activity	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	7.4x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Klk5^{tm2b(KOMP)Wtsi}	homozygote	Early adult	6.01x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Klk5.

Associated images

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Histopathology

There is no histopathology data found for Klk5.

IMPC related publications

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External links

No external links available for Klk5.

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*Klk5^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Klk5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Klk5^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Klk5^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Klk5^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Klk5^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Klk5^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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