Fbxw9 | F-box and WD-40 domain protein 9

GeneMGI:1915878Synonyms: 1110017H11Rik, Fbw9

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Vision/eye Respiratory system Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



preweaning lethality, incomplete penetrance	2 supporting datasets	Fbxw9^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Fbxw9^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.57x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Fbxw9^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Fbxw9^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal trachea morphology	1 supporting dataset	Fbxw9^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Fbxw9^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
absent lymph nodes	1 supporting dataset	Fbxw9^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal thyroid gland morphology	1 supporting dataset	Fbxw9^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
absent spleen	1 supporting dataset	Fbxw9^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxw9.

Associated images

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Histopathology

There is no histopathology data found for Fbxw9.

IMPC related publications

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External links

No external links available for Fbxw9.

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*Fbxw9^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fbxw9^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbxw9^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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