Letmd1 | LETM1 domain containing 1

GeneMGI:1915864Synonyms: 1110019O13Rik, HCCR-2, +1 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased startle reflex	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Late adult	1.55x10^-5
increased total body fat amount	2 supporting datasets	Letmd1^{em1(IMPC)Kmpc}	homozygote	Late adult	1.68x10^-6
decreased prepulse inhibition	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Late adult	5.68x10^-5
increased freezing behavior	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Late adult	3.56x10^-5
decreased bone mineral density	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Late adult	1.16x10^-5
increased fasting circulating glucose level	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Early adult	4.15x10^-6
increased freezing behavior	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Early adult	1.43x10^-6
increased heart weight	1 supporting dataset	Letmd1^{em1(IMPC)Kmpc}	homozygote	Late adult	8.16x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Letmd1.

Associated images

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Histopathology

There is no histopathology data found for Letmd1.

IMPC related publications

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External links

No external links available for Letmd1.

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*Letmd1^{em1(IMPC)Kmpc}*	Indel	‌	mouse
*Letmd1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Letmd1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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