Qars1 | glutaminyl-tRNA synthetase 1

GeneMGI:1915851Synonyms: 1200016L19Rik, Qars, +1 more

Physiological systems

23 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Integument Muscle Nervous system Vision/eye Mortality/aging

18 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal skeletal muscle morphology	1 supporting dataset	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Qars1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Qars1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal eye morphology	2 supporting datasets	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	7.59x10^-7
abnormal brain morphology	1 supporting dataset	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Qars1^em1(IMPC)Mbp	heterozygote	Early adult	1.05x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Qars1.

Associated images

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Histopathology

There is no histopathology data found for Qars1.

IMPC related publications

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External links

No external links available for Qars1.

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*Qars1^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Qars1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Qars1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Qars1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Qars1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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