Rtn4 | reticulon 4

GeneMGI:1915835Synonyms: 1110020G17Rik, Nogo-A, +4 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

15 No significant impact

4 Not tested

Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased startle reflex1 supporting datasetRtn4em1(IMPC)HmguhomozygoteEarly adult7.83x10-17 
decreased prepulse inhibition6 supporting datasetsRtn4em1(IMPC)HmguhomozygoteEarly adult1.35x10-10 
abnormal auditory brainstem response1 supporting datasetRtn4em1(IMPC)HmguhomozygoteEarly adult2.88x10-5 
abnormal startle reflex1 supporting datasetRtn4em1(IMPC)HmguhomozygoteEarly adult7.67x10-5 
decreased bone mineral content1 supporting datasetRtn4em1(IMPC)HmguhomozygoteEarly adult3.46x10-5 
increased mean platelet volume1 supporting datasetRtn4em1(IMPC)HmguhomozygoteEarly adult3.15x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rtn4em1(IMPC)HmguExon Deletionmouse
Rtn4tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell

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