Chn1 | chimerin 1

GeneMGI:1915674Synonyms: ARHGAP2, alpha1 chimaerin, +5 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

6 Not tested

Gene metrics:17Significant phenotypes
2Associated diseases
Expression examined in:50Adult tissues
50Embryo tissues

Phenotypes

hyperactivity6 supporting datasetsChn1tm1.1(KOMP)VlcghomozygoteEarly adult3.36x10-24 
abnormal sleep behavior2 supporting datasetsChn1tm1.1(KOMP)VlcghomozygoteEarly adult1.67x10-5 
increased circulating alkaline phosphatase level1 supporting datasetChn1tm1.1(KOMP)VlcghomozygoteEarly adult5.08x10-5 
increased circulating sodium level1 supporting datasetChn1tm1.1(KOMP)VlcghomozygoteEarly adult6.36x10-6 
decreased circulating glucose level1 supporting datasetChn1em1(IMPC)JheterozygoteEarly adult3.72x10-14 
increased mean corpuscular volume1 supporting datasetChn1tm1.1(KOMP)VlcghomozygoteEarly adult1.45x10-13 
increased hematocrit1 supporting datasetChn1tm1.1(KOMP)VlcghomozygoteEarly adult8.73x10-8 
increased circulating sodium level1 supporting datasetChn1em1(IMPC)JheterozygoteEarly adult7.53x10-6 
increased lean body mass1 supporting datasetChn1tm1.1(KOMP)VlcghomozygoteEarly adult3.77x10-5 
impaired righting response2 supporting datasetsChn1tm1.1(KOMP)VlcghomozygoteEarly adult1.19x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Chn1em1(IMPC)JExon Deletionmouse
Chn1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
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Chn1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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