Aph1c | aph1 homolog C, gamma secretase subunit

GeneMGI:1915568Synonyms: 0610008A10Rik

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Pigmentation Integument Nervous system Behavior/neurological

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



abnormal coat/hair pigmentation	1 supporting dataset	Aph1c^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8x10^-13
increased prepulse inhibition	1 supporting dataset	Aph1c^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.2x10^-5
decreased grip strength	1 supporting dataset	Aph1c^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.03x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aph1c.

Associated images

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Histopathology

There is no histopathology data found for Aph1c.

IMPC related publications

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External links

No external links available for Aph1c.

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*Aph1c^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Aph1c^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aph1c^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Aph1c^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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