Pdhb | pyruvate dehydrogenase (lipoamide) beta
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Vision/eye Cardiovascular system Mortality/aging Craniofacial
13 No significant impact
4 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal neural tube morphology | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Pdhbem1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Pdhbem1(IMPC)Bay | heterozygote | Early adult | 5.08x10-5 | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| abnormal somite shape | 1 supporting dataset | Pdhbem1(IMPC)Bay | homozygote | E9.5 | N/A * |
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External links
No external links available for Pdhb.
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| Pdhbem1(IMPC)Bay | Exon Deletion | | mouse |
| Pdhbtm231174(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |