Leprotl1 | leptin receptor overlapping transcript-like 1

GeneMGI:1915442Synonyms: 1520402O14Rik, 1110067H13Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Muscle Behavior/neurological Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	2 supporting datasets	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.22x10^-7
decreased anxiety-related response	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.68x10^-5
increased cardiac muscle contractility	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.87x10^-5
thick ventricular wall	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.04x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.79x10^-7
increased circulating phosphate level	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.87x10^-5
abnormal behavior	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.89x10^-5
decreased thigmotaxis	2 supporting datasets	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.32x10^-7
limb grasping	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.91x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.35x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Leprotl1.

Associated images

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Histopathology

There is no histopathology data found for Leprotl1.

IMPC related publications

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External links

No external links available for Leprotl1.

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*Leprotl1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Leprotl1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Leprotl1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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