Upf3b | UPF3 regulator of nonsense transcripts homolog B (yeast)

GeneMGI:1915384Synonyms: RENT3B, 5730594O13Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased vertical activity	1 supporting dataset	Upf3b^em1(IMPC)Tcp	homozygote	Early adult	7.43x10^-5
increased fasting circulating glucose level	1 supporting dataset	Upf3b^em1(IMPC)Tcp	homozygote	Early adult	6.02x10^-5
increased neutrophil cell number	1 supporting dataset	Upf3b^em1(IMPC)Tcp	homozygote	Early adult	5.88x10^-6
small thymus	1 supporting dataset	Upf3b^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased freezing behavior	1 supporting dataset	Upf3b^em1(IMPC)Tcp	homozygote	Early adult	1x10^-8
hyperactivity	2 supporting datasets	Upf3b^em1(IMPC)Tcp	homozygote	Early adult	2.02x10^-10
hyperactivity	5 supporting datasets	Upf3b^em1(IMPC)Tcp	hemizygote	Early adult	3.77x10^-13
abnormal sternum morphology	1 supporting dataset	Upf3b^em1(IMPC)Tcp	hemizygote	Early adult	N/A ^*
small thymus	1 supporting dataset	Upf3b^em1(IMPC)Tcp	hemizygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Upf3b^em1(IMPC)Tcp	hemizygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Upf3b.

Associated images

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Histopathology

There is no histopathology data found for Upf3b.

IMPC related publications

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External links

No external links available for Upf3b.

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*Upf3b^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Upf3b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Upf3b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Upf3b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Upf3b^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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