Zwilch | zwilch kinetochore protein

GeneMGI:1915264Synonyms: 2310031L18Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta vasculature	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased circulating iron level	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.83x10^-6
abnormal placenta size	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Zwilch^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.32x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Zwilch.

Associated images

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Histopathology

There is no histopathology data found for Zwilch.

IMPC related publications

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External links

No external links available for Zwilch.

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*Zwilch^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Zwilch^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Zwilch^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Zwilch^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Zwilch^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Zwilch^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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