Npc2 | NPC intracellular cholesterol transporter 2

GeneMGI:1915213Synonyms: HE1, 2700012J19Rik

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Endocrine/exocrine gland

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating potassium level	1 supporting dataset	Npc2^{tm1e.1(EUCOMM)Wtsi}	heterozygote	Early adult	2.52x10^-15
small adrenal glands	1 supporting dataset	Npc2^{tm1e.1(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Npc2.

Associated images

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Histopathology

There is no histopathology data found for Npc2.

IMPC related publications

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External links

No external links available for Npc2.

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*Npc2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Npc2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Npc2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Npc2^{tm1e.1(EUCOMM)Wtsi}*	Promoter excision from Targeted, non-conditional allele	‌	mouse

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