Dnajb11 | DnaJ heat shock protein family (Hsp40) member B11

GeneMGI:1915088Synonyms: ABBP-2, 1810031F23Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



dilated aorta	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.82x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.47x10^-12
increased startle reflex	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.11x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.82x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.53x10^-11
persistence of hyaloid vascular system	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.47x10^-7
abnormal retina morphology	1 supporting dataset	Dnajb11^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.49x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnajb11.

Associated images

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Histopathology

There is no histopathology data found for Dnajb11.

IMPC related publications

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External links

No external links available for Dnajb11.

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*Dnajb11^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dnajb11^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dnajb11^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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