Kat8 | K(lysine) acetyltransferase 8

GeneMGI:1915023Synonyms: 2010203C02Rik, 5830450F21Rik, +3 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cataract	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	9.23x10^-5
abnormal kidney morphology	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Kat8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Kat8^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
small kidney	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	6.88x10^-6
enlarged lymph nodes	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased locomotor activity	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	1.21x10^-7
abnormal vitreous body morphology	1 supporting dataset	Kat8^em1(IMPC)Mbp	heterozygote	Early adult	7.3x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kat8.

Associated images

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Histopathology

There is no histopathology data found for Kat8.

IMPC related publications

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External links

No external links available for Kat8.

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*Kat8^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Kat8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Kat8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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