Nsmce1 | NSE1 homolog, SMC5-SMC6 complex component

GeneMGI:1914961Synonyms: 2510027N19Rik

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Embryo Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating total protein level	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	heterozygote	Early adult	2.91x10^-5
abnormal retina morphology	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.68x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	homozygote	E12.5	N/A ^*
abnormal retina blood vessel morphology	2 supporting datasets	Nsmce1^{em1(IMPC)Wtsi}	heterozygote	Early adult	1.36x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
hydrometra	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	heterozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	heterozygote	Early adult	4.95x10^-6
abnormal embryo size	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	homozygote	E9.5	N/A ^*
abnormal uterus morphology	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	heterozygote	Early adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Nsmce1^{em1(IMPC)Wtsi}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nsmce1.

Associated images

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Histopathology

There is no histopathology data found for Nsmce1.

IMPC related publications

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External links

No external links available for Nsmce1.

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*Nsmce1^{em1(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Nsmce1^{tm47221(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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