Alkbh8 | alkB homolog 8, tRNA methyltransferase

GeneMGI:1914917Synonyms: 4930562C03Rik, Abh8, +2 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Renal/urinary system

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased mean platelet volume	1 supporting dataset	Alkbh8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.4x10^-7
increased mean corpuscular volume	1 supporting dataset	Alkbh8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.58x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Alkbh8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.5x10^-5
abnormal kidney morphology	1 supporting dataset	Alkbh8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Alkbh8.

Associated images

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Histopathology

There is no histopathology data found for Alkbh8.

IMPC related publications

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External links

No external links available for Alkbh8.

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*Alkbh8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Alkbh8^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Alkbh8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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