Alg2 | ALG2 alpha-1,3/1,6-mannosyltransferase
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues
| decreased fasting circulating glucose level | 1 supporting dataset | Alg2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.61x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Alg2tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal digit morphology | 1 supporting dataset | Alg2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 6.25x10-5 | ||
| increased circulating insulin level | 1 supporting dataset | Alg2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.66x10-6 | ||
| impaired righting response | 1 supporting dataset | Alg2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.1x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Alg2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
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External links
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| Alg2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Alg2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Alg2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |