Abcg8 | ATP binding cassette subfamily G member 8

GeneMGI:1914720Synonyms: Sterolin-2, 1300003C16Rik

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Muscle Vision/eye Liver/biliary system Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system

10 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:40Significant phenotypes

4Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Phy. System:



increased circulating triglyceride level	1 supporting dataset	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.98x10^-37
abnormal heart left ventricle morphology	1 supporting dataset	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.92x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.49x10^-15
increased cardiac muscle contractility	2 supporting datasets	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.76x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.73x10^-8
abnormal spleen morphology	2 supporting datasets	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased lung elastance	2 supporting datasets	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.44x10^-7
increased red blood cell distribution width	1 supporting dataset	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.81x10^-12
increased circulating creatinine level	1 supporting dataset	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.5x10^-5
abnormal liver morphology	2 supporting datasets	Abcg8^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Abcg8.

Associated images

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Histopathology

There is no histopathology data found for Abcg8.

IMPC related publications

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External links

No external links available for Abcg8.

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*Abcg8^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Abcg8^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Abcg8^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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