Mmd | monocyte to macrophage differentiation-associated

GeneMGI:1914718Synonyms: 1200017E07Rik, Paqr11, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased total retina thickness2 supporting datasetsMmdem1(IMPC)HmguhomozygoteEarly adult1.05x10-8 
increased grip strength1 supporting datasetMmdem1(IMPC)HmguhomozygoteEarly adult6.46x10-5 
decreased locomotor activity2 supporting datasetsMmdem1(IMPC)HmguhomozygoteEarly adult4.06x10-7 
increased circulating alkaline phosphatase level1 supporting datasetMmdem1(IMPC)HmguhomozygoteEarly adult3.97x10-6 
abnormal vitreous body morphology1 supporting datasetMmdem1(IMPC)HmguhomozygoteEarly adult1.5x10-6 
decreased body length1 supporting datasetMmdem1(IMPC)HmguhomozygoteEarly adult2.08x10-5 
increased circulating aspartate transaminase level1 supporting datasetMmdem1(IMPC)HmguhomozygoteEarly adult1.77x10-5 
abnormal retina morphology1 supporting datasetMmdem1(IMPC)HmguhomozygoteEarly adult2.92x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mmdem1(IMPC)HmguExon Deletionmouse
Mmdtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Mmdtm44219(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Mmdtm44219(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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