Stk35 | serine/threonine kinase 35

GeneMGI:1914583Synonyms: CLIK1, CLP-36 interacting kinase, +1 more

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

anophthalmia1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult7.74x10-6 
hyperactivity5 supporting datasetsStk35em1(IMPC)JhomozygoteEarly adult1.03x10-8 
increased circulating alanine transaminase level1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult2.37x10-6 
decreased mean corpuscular hemoglobin1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult2.64x10-6 
abnormal bone structure1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult3.71x10-5 
cornea vascularization1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult2.5x10-6 
increased vertical activity1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult4.58x10-5 
cornea opacity1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult2.55x10-6 
abnormal vocalization1 supporting datasetStk35em1(IMPC)JhomozygoteEarly adult1.5x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Stk35em1(IMPC)JExon Deletionmouse
Stk35tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Stk35tm445988(L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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